Neuroglobin expression in ischemic stroke

Abstract

Background and Purpose:We investigated whether neuroglobin, a neuronal protein that protects neurons from hypoxic-ischemic injury, is upregulated in ischemic stroke. Methods: Neuroglobin immunoreactivity was measured in brain tissue from control subjects and patients with ischemic stroke. Results-Neuroglobin was detected in several brain areas, and its expression was increased in the cortical peri-infarct region after stroke. Conclusions:s: Ischemic stroke increases expression of the neuroprotective protein neuroglobin, suggesting neuroglobin may represent a novel target for stroke therapy. © 2010 American Heart Association, Inc.