This is an in-depth review of the history of quinacrine as well as its pharmacokinetic properties and established record of safety as an FDA-approved drug. The potential uses of quinacrine as an anti-cancer agent are discussed with particular attention to its actions on nuclear proteins, the arachidonic acid pathway, and multi-drug resistance, as well as its actions on signaling proteins in the cytoplasm. In particular, quinacrine's role on the NF-κB, p53, and AKT pathways are summarized. © 2011 Ehsanian et al; licensee BioMed Central Ltd.
CITATION STYLE
Ehsanian, R., Van Waes, C., & Feller, S. M. (2011). Beyond DNA binding - A review of the potential mechanisms mediating quinacrine’s therapeutic activities in parasitic infections, inflammation, and cancers. Cell Communication and Signaling. https://doi.org/10.1186/1478-811X-9-13
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