Synthesis and characterization of hydroxyapatite/alumina ceramic nanocomposites for biomedical applications

Abstract

In the present work, nanocrystalline hydroxyapatite/alumina (HAp-Al2O3) composite was prepared under specially designed stir-type hydrothermal reactor. The composite was prepared at two different temperatures under autogenous pressure and analysed for crystallinity, size, shape, composition and thermomechanical stability. The electron microscopy study shows the formation of HAp-Al2O3 composite nanorods with uniform distribution. The thermogravimetry analysis reveals better thermomechanical property with minimal weight loss at increased temperature. The effect of different concentrations of HAp-Al2O3 composite powders against MG63 human osteosarcoma cell lines shows excellent compatibility (80%) at high concentration of 200 µg ml-1. These studies facilitate the formation of biocompatible HAp-Al2O3 composite nanorods for biomedical applications.