Preparation of enantiopure 2-acylazetidines and their reactions with chloroformates

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Abstract

Enantiopure 1-phenylethylazetidine-2-carboxylates and 2-acylazetidines were prepared and reacted with chloroformates to yield α-chloro-γ-amino butyric acid esters and ketones from ring opening reaction of azetidinium ion intermediate in a completely regio- and stereoselective manner. © 2006 Elsevier Ltd. All rights reserved.

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Ma, S. ho, Yoon, D. H., Ha, H. J., & Lee, W. K. (2007). Preparation of enantiopure 2-acylazetidines and their reactions with chloroformates. Tetrahedron Letters, 48(2), 269–271. https://doi.org/10.1016/j.tetlet.2006.11.033

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