Pengaruh Ekstrak Etanol Brokoli Terhadap Histologi Tuba Fallopi yang Dipapar MSG

Abstract

Background: the habit of consuming fast food in Indonesia reaches 69%/day. MSG can endanger health, especially female reproductive organs it can cause infertility. Objective: to prove the effect of broccoli ethanol extract in increasing total secretory epithelial cells and thickness of fallopian tube smooth muscle exposed to MSG. Method: this design is Randomized Post Test Only by comparing the variables studied between treatment groups. The group was divided into 5 namely: K(-) not given MSG exposure and broccoli ethanol extract; K(+) given MSG exposure of 0.7 mg/gBB; P1 (MSG 0.7 mg/gBB+500 mg/kgBB of broccoli ethanol extract); P2 (MSG 0.7 mg/gBB+1000 mg/kgBB of broccoli ethanol extract); P3 (MSG 0.7 mg/gBB+2000 mg/kgBB of broccoli ethanol extract). Provision of treatment carried out for 28 days. The termination was carried out on day 29 when the rat was in the proestrus phase, then the HE was stained to find out the histopathological picture of the fallopian tube of the mouse then observed under a microscope. Results: ANOVA test on mean secretory epithelial cells produced a significant difference (p = 0,000 or <0.05), while the HSD test results proved that not all treatment groups obtained significant differences. The amount of thick muscle layer shows that there is no significant difference. Conclusion: Broccoli ethanol extract was able to increase the mean of secretory epithelial cells and the thickness of the smooth muscle layer of the fallopian tubes exposed to MSG, although there were no significant differences between groups.