A New Twist on a Classic: Enhancing Radioiodine Uptake in Advanced Thyroid Cancer

Abstract

Advanced differentiated thyroid cancer that is resistant to radioactive iodine therapy may become responsive with a unique treatment combination of chloroquine and vorinostat. This treatment was demonstrated in cellular and animal models of thyroid cancer to inhibit endocytosis of the plasma membrane- bound iodine transporter, NIS, and restore iodine uptake.