Curcumin Potentially to Increase Athlete Performance Through Regulated Mitochondrial Biogenesis

Abstract

A marked example of muscle adaptations occurs in the mitochondria following exercise training. Endurance training has potential to enhance metabolic characteristics in the skeletal muscle, including mitochondrial biogenesis and glucose transporter 4 (GLUT4). Polyphenol have been shown to activate cAMP, therefore, currently being intensively investigated as potential inducer of mitochondrial biogenesis through the deacetylation-mediated activation of PGC-1α. The polyphenol curcumin is components of curcuma longa L, have ability to regulated mitochondria biogenesis on skeletal muscle will review in this chapter. The examination the effect of combination of endurance training and curcumin treatment to increase mitochondrial biogenesis seem look like through AMPK, SIRT1 and PGC-1α pathway. Furthermore, in this review we also explained the direct target how curcumin treatment increase mitochondrial biogenesis. We focus on the second messenger cAMP which involve to regulated mitochondrial biogenesis. Indeed, previous study indicated that cAMP be the important target on endurance exercise training to increase mitochondrial biogenesis. The last, the current review determined how curcumin have ability to increase mitochondrial biogenesis on skeletal muscle with examine phosphorylation of PDE4A which involve to convert cAMP to AMP. Based on our previous experiments we conclude that indeed curcumin treatment have ability to increase performance through regulated mitochondria biogenesis on skeletal muscle.