Research progress on chemical constructions and pharmacological effects of Terminaliae Belliricae Fructus and predictive analysis of its quality markers

Abstract

Maohezi (Terminaliae Belliricae Fructus) is a commonly used herb in Tibetan medicine. It is widely used in traditional Chinese medicine and multi-ethnic medicine with long history. Modern researches have shown that it mainly contains phenolic acids, tannins, flavonoids, terpenoids, steroids, lignans and other chemical components, with hepatoprotective, hypoglycemic activity, blood lipids regulation and antitumor pharmacological effects. Based on a summary of the chemical constituents and pharmacological effects of Terminaliae Belliricae Fructus, combining with the research progress of its quality control, Q-Marker predictions were made in terms of traditional medicinal properties, traditional efficacy, chemical constituents measurability and pharmacokinetics. Gallic acid, ellagic acid, corilagin, methyl gallate, chebulinic acid, tannic acid, quinic acid, 6-gingerol and catechins can be used as the main Q-Marker of Terminaliae Belliricae Fructus, in order to provide a reference for further research and rational establishment of quality standards of Terminaliae Belliricae Fructus.