Transport and dynamic analysis of magnetic nanoparticles in brain microvascular vessels

Abstract

The number of patients with neurodegenerative disorders is growing rapidly, and it poses a major concern to discover effective therapies. The well-known deep brain stimulation as a treatment for Parkinson's disease has irredeemable impact on the brain tissue. Magnetothermal stimulation is a good alternative though, it is still invasive due to stereotactic injection for nanoparticle delivery. A good solution to this issue is to take advantage of microvasculature and excite the nanoparticles inside the brain capillaries. Hence, transport and dynamic analysis of blood flow through a brain capillary is crucial. This article presents a two-dimensional theoretical study of a blood flow with magnetic nanoparticles through a capillary when exposed to an alternating magnetic field. The magnetic nanoparticles are localized within the domain over time. The particle transport impacts and the dynamic interactions with the blood flow are elaborately investigated.