Transition metal containing ionic liquid-assisted one-pot synthesis of pyrazoles at room temperature

Abstract

Abstract: The feasible and one of the green ways to synthesize organic compounds especially pyrazole and its derivatives are systematically presented. The one-pot synthesis of pyrazole was achieved by condensation of various hydrazines and 1,3-diketone derivatives at room temperature using transition metal-based ionic liquids. Herein, the unique combination of Fe(III) with ionic liquid is explored and utilized as an efficient homogeneous catalyst for the synthesis of pyrazole and its derivatives. The homogenous catalyst thus synthesised was re-used up to the fourth cycle (with 90%, 88%, 84%, 78% yields respectively). Graphic abstract: Pyrazoles are synthesized in the presence of transition metal-based ionic liquids at room temperature. From the green chemistry perspective, ionic liquids are considered as green solvents which have gained remarkable attention because of its non-toxic, non-corrosive and non-flammable nature while the presence of transition metal as a part of counter anion gives it more catalytic activity. [Figure not available: see fulltext.].