Androgens up-regulate transcription of the notch inhibitor numb in C2C12 myoblasts via wnt/β-catenin signaling to t cell factor elements in the numb promoter

Abstract

Background: Androgenic, Wnt, and Notch pathways regulate progenitor development through unknown mechanisms. Results: Up-regulation of Numb was blocked by Wnt inhibitors and required β-catenin. Nandrolone promoted binding of β-catenin to the Numb promoter and thereby increased its activity through Tcf bound at two consensus sites. Conclusion: Wnt/β-catenin signaling mediates nandrolone-induced Numb transcription. Significance: AR signaling regulates Wnt-Notch interaction via Numb, a newly identified Wnt target gene. © 2013 by The American Society.