Comparative studies of different quinolinone derivatives as donors in fluorescence-resonance-energy transfer (FRET) - Systems in combination with a (bathophenanthroline)ruthenium(II) complex as acceptor

Abstract

We describe the preparation as well as a detailed photophysical study of Fmoc-amino acid building blocks carrying different carbostyril (=quinolin-2(1H)-one) heterocycles as donors in a FRET (fluorescence-resonance- energy transfer) system in combination with a [Ru II(bathophenanthroline)] complex (bathophenanthroline = 4,7-diphenyl-1,10-phenanthroline). The efforts resulted in a clear preference for building block 16 due to its ease of synthesis (Scheme 2), its chemical robustness, and the FRET efficiency when incorporated into peptides. © 2009 Verlag Helvetica Chimica Acta AG.