Palladium-catalyzed 2,2,2-trifluoroethylation of organoboronic acids and esters

Abstract

Trifluoroethylation: Aryl boronic acids can be catalytically trifluoroethylated with the readily available reagent CF3CH 2I (see scheme, dba=dibenzylideneacetone). The reaction tolerates a variety of functional groups and can be extended to the trifluoroethylation of aryl or alkenyl boronic esters. The method is also suitable for the late-stage installation of the CF3CH2 group into target molecules. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.