The antiadhesive and antithrombotic effects of the nitric oxide donor SIN-1 are combined with a decreased vasoconstriction in a porcine model of balloon angioplasty

Abstract

Nitric oxide has been reported to modulate platelet and neutrophil interactions with the arterial wall. In this study, we investigated the effects of the nitric oxide donor 3-morpholino-sydnonimine (SIN-l) on platelet and neutrophil adhesion, and the vasomotor response, in a porcine model of angioplasty. Carotid arterial injury was produced by balloon dilation in control (n=10) and treated (SIN-1; 10 μg/kg + 1 μg/kg/min, IV) (n=8) pigs. At the site of deep arterial injury, the average platelet adhesion was 53.6±11.3X106/cm2 in the control animals and was significantly inhibited by more than 70%, to 15.1±4.1x106/cm2 (P