Microwave-assisted aqueous reactions: An efficient route to benzodiazepines

Abstract

Microwave-assisted three-component reaction has been established for the synthesis of benzodiazepines. This reaction promoted by HOAc was conducted by using readily available and inexpensive starting materials in water under microwave irradiation. The present green synthesis shows fascinating characteristics such as the use of water as the reaction solution, concise one-pot conditions, short reaction periods, easy purification, and reduced waste production without the use of any strong acids or metal promoters.