Integrated reactions based on the sequential addition to α-imino esters

Abstract

This article summarizes integrated sequential reactions with a-imino esters, where the umpolung addition reaction to the imino nitrogen followed by the second addition or oxidation is the crucial step. The following four types of reactions are discussed: (1) tandem N-ethylation/Mannich reaction; (2) N-alkylation/ addition reaction; (3) synthesis of indolin-3-ones and tetrahydro-4-quinolones; (4) regioselective tandem N-alkylation/ C-acylation of ß,γ-alkynyl a-imino esters. © 2014 IUPAC & De Gruyter.