Recent Deep Learning Methodology Development for RNA–RNA Interaction Prediction

Abstract

Genetic regulation of organisms involves complicated RNA–RNA interactions (RRIs) among messenger RNA (mRNA), microRNA (miRNA), and long non-coding RNA (lncRNA). Detect-ing RRIs is beneficial for discovering biological mechanisms as well as designing new drugs. In recent years, with more and more experimentally verified RNA–RNA interactions being deposited into databases, statistical machine learning, especially recent deep-learning-based automatic algorithms, have been widely applied to RRI prediction with remarkable success. This paper first gives a brief introduction to the traditional machine learning methods applied on RRI prediction and benchmark databases for training the models, and then provides a recent methodology overview of deep learning models in the prediction of microRNA (miRNA)–mRNA interactions and long non-coding RNA (lncRNA)–miRNA interactions.