Shear wave elastography predicts hepatocellular carcinoma risk in hepatitis C patients after sustained virological response

Abstract

Aim To evaluate the relationship between fibrosis and HCC after sustained virological response (SVR) to treatment for chronic hepatitis C (HCV). Methods This single-center study retrospectively evaluated 196 patients who achieved SVR after HCV infection. The associations of risk factors with HCC development after HCV eradication were evaluated using univariate and multivariate Cox proportional hazards regression models. Results Among the 196 patients, 8 patients (4.1%) developed HCC after SVR during a median follow-up of 26 months. Multivariate analyses revealed that HCC development was independently associated with age of 75 years (risk ratio [RR] = 35.16), α- fetoprotein levels of 6 ng/mL (RR = 40.30), and SWE results of 11 kPa (RR = 28.71). Conclusions Our findings indicate that SWE may facilitate HCC surveillance after SVR and the identification of patients who have an increased risk of HCC after HCV clearance.