Arylsulfatase K, a novel lysosomal sulfatase

Abstract

Background: Human sulfatases play key roles in physiology and cause numerous pathological conditions upon deficiency/misregulation. Results: ARSK is ubiquitously expressed, localizes to lysosomes, and shows arylsulfatase activity at acidic pH. Conclusion: ARSK is a novel lysosomal sulfatase acting on a ubiquitous substrate. Significance: ARSK functions in lysosomal degradation, possibly of glycosaminoglycans, and, in all probability, is associated with a non-classified lysosomal storage disorder. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.