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Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics after Administration in Patients with Severe Coronavirus Disease 2019

Open Forum Infectious Diseases (2021) 8(8)
DOI: 10.1093/ofid/ofab385
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Abstract

We characterized the antibody composition of coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) and the immunologic responses of hospitalized COVID-19 patients after receiving CCP or nonimmune fresh frozen plasma. Despite selection of CCP with significantly higher total immunoglobulin G than recipients, neutralizing antibody levels did not differ between donor plasma and CCP recipients.

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Bainbridge, E. D., Hsue, P. Y., Esensten, J. H., Lynch, K. L., Hendrickson, C. M., Doernberg, S. B., … Luetkemeyer, A. F. (2021). Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics after Administration in Patients with Severe Coronavirus Disease 2019. Open Forum Infectious Diseases, 8(8). https://doi.org/10.1093/ofid/ofab385

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