Some Items of Interest to Process R&D Chemists and Engineers

Abstract

Article Sections: Investigation of Temperature Cycling with Coupled Vessels for Efficient Deracemization of NMPA Rapid Assessment of Crystal Nucleation and Growth Kinetics: Comparison of Seeded and Unseeded Experiments Capturing Primary Ozonides for syn-Dihydroxylation of Olefins Catalytic Asymmetric Visible-Light De Mayo Reaction by Zirconium Tetrachloride–Chiral Phosphoric Acid Complex Automated and Material-Sparing Workflow for the Measurement of Crystal Nucleation and Growth Kinetics Reinforcement Learning Optimization of Reaction Routes on the Basis of Large, Hybrid Organic Chemistry–Synthetic Biological Reaction Network Data Visible-Light-Mediated Aza Paternò–Büchi Reaction of Acyclic Oximes and Alkenes for the Synthesis of Monocyclic Azetidines Unbiasing Retrosynthesis Language Models with Disconnection Prompts Data Sharing in Chemistry: Lessons Learned and a Case for Mandating Structured Reaction Data What Enables and Blocks Synthetic Chemistry Methods in Becoming Industrially Significant? Nickel–Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers On the Mechanism and Selectivity of Palladium-Catalyzed C(sp3)–H Arylation of Pyrrolidines and Piperidines at Unactivated C4 Positions: Discovery of an Improved Dimethylaminoquinoline Amide Directing Group From Cycloalkanols to Heterocycles via Nitrogen Insertion What Does It Mean That “Something Is Green”? The Fundamentals of a Unified Greenness Theory Mild Installation of Piperidines on 4-Alkylpyridines Catalytic Enantioselective Synthesis of 3-Piperidines from Arylboronic Acids and Pyridine Liquid/Liquid Heterogeneous Reaction Monitoring: Insights into Biphasic Suzuki–Miyaura Cross-Coupling Cumulative Complexity Meta-metrics as an Efficiency Measure and Predictor of Process Mass Intensity during Synthetic Route Design Access to Trifluoromethyl Ketones from Alkyl Bromides and Trifluoroacetic Anhydride by Photocatalysis Oxetane-, Azetidine-, and Bicyclopentane-Bearing N-Heterocycles from Ynones: Scaffold Diversification via Ruthenium-Catalyzed Oxidative Alkynylation Development of Photoredox Cross-Electrophile Coupling of Strained Heterocycles with Aryl Bromides Using High-Throughput Experimentation for Library Construction Efficient C(sp3)–H Carbonylation of Light and Heavy Hydrocarbons with Carbon Monoxide via Hydrogen Atom Transfer Photocatalysis in Flow Forging C–S Bonds on the Azetidine Ring by Continuous Flow Photochemical Addition of Thiols and Disulfides to Azetines 2,5-Disubstituted Bicyclo[2.1.1]hexanes as Rigidified Cyclopentane Variants 2,6-Bis(pyrazol-1-yl)pyridine as a General Ligand for the Negishi Alkylation of Alkylpyridinium Salts Electrochemically Driven Deoxygenative Borylation of Alcohols and Carbonyl Compounds Enantioselective Construction of Carbocyclic and Heterocyclic Tertiary Boronic Esters by Conjunctive Cross-Coupling Reaction Enhancing Substrate–Metal Catalyst Affinity via Hydrogen Bonding: Palladium(II)-Catalyzed β-C(sp3)–H Bromination of Free Carboxylic Acids Late-Stage Aryl C–H Bond Cyclopropenylation with Cyclopropenium Cation Molybdenum-Catalyzed Regio- and Enantioselective Amination of Allylic Carbonates: Total Synthesis of (S)-Clopidogrel Enantioselective Transfer Hydrogenative Cycloaddition Unlocks the Total Synthesis of SF2446 B3, an Aglycone of Arenimycin and SF2446 Type II Polyketide Antibiotics Asymmetric Arene Hydrogenation: Toward Sustainability and Application