Synthesis of a novel triphenyltin(IV) derivative of 2-mercaptonicotinic acid with potent cytotoxicity in vitro

Abstract

A novel triphenyltin(IV) derivative of 2-mercaptonicotinic acid (H 2mna) of formula {[(C6H5)3Sn] 2(mna)·[(CH3)2CO]} (1) has been synthesized and characterized by elemental analysis and 1H, 13C-NMR, and FT-IR spectroscopic techniques. The crystal structure of complex (1) has been determined by single crystal X-ray diffraction analysis at 173(1) K. Compound (1) contains two triphenyltin moieties linked by a doubly de-protonated 2-mercaptonicotinic acid (H2mna). It is an example of a pentacoordinated Ph3SnXY system with an axial-equatorial arrangement of the phenyl groups at Sn(1). Compound (1), exhibits potent, in vitro, cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (PAH, benzo[a]pyrene) carcinogenesis.