Benzotriazole-assisted synthesis of monoacyl α-aminoglycines

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Abstract

Adducts (8,12), derived from benzotriazole (7), glyoxylic ester (6) or acid (11), and an amide (5), react with ammonia in a novel, convenient route to monoacylated α-aminoglycines (9,13) useful for the synthesis of peptide analogues.

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Katritzky, A. R., Urogdi, L., & Mayence, A. (1989). Benzotriazole-assisted synthesis of monoacyl α-aminoglycines. Journal of the Chemical Society, Chemical Communications, (6), 337–338. https://doi.org/10.1039/C39890000337

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