Comparative Trial of Nafoxidine and Ethinyloestradiol in Advanced Breast Cancer: An E.O.R.T.C. Study

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Abstract

A randomized clinical trial of nafoxidine, a non–steroidal oestrogen antagonist, and ethinyloestradiol in postmenopausal patients with advanced breast cancer produced objective remissions in 31% of 49 women receiving nafoxidine and in 14% of 49 receiving ethinyloestradiol. The difference in remission rates was almost significant (0.05

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Heuson, J. C., Engelsman, E., Blonk-Van Der Wijst, J., Maass, H., Nowakowski, H., Drochmans, A., … Gorins, A. (1975). Comparative Trial of Nafoxidine and Ethinyloestradiol in Advanced Breast Cancer: An E.O.R.T.C. Study. British Medical Journal, 2(5973), 711–713. https://doi.org/10.1136/bmj.2.5973.711

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