Identification and expression of G-proteins in human myometrium: Up-regulation of Gαs in pregnancy

Abstract

We report that human myometrium contains Gα14, Gα13, Gα12, and Gα11, which are expressed at similar levels in tissues from pregnant and nonpregnant women. Gα12 is also expressed, but at a slightly reduced level, in tissue taken from pregnant compared to nonpregnant donors. The major finding of this investigation is the substantial increase in Gαs expression in pregnant myometrium. The increase in Gαs levels may play a crucial role in maintaining relaxation of the uterus by favoring cAMP formation during pregnancy.