Versatile chip-based nanoscopy becomes ready for histopathology assessment

Abstract

Nanoscopy is a mature technology used routinely in life science to obtain images well below the optical diffraction limit. But the use of nanoscopy in histopathology assessment is very limited mostly due to the low throughput of traditional nanoscopic techniques. So far, Chip-nanoscopy, nanoscopy in which sample illumination is performed by an integrated photonic chip instead of bulk optics, has been shown to provide an enhanced field of view and throughput for cell biology. Now, a new development shows that chip-nanoscopy also offers interesting progress for the study of histological samples offering a complementary technique to electron microscopy for histopathology assessment.