Synthesis and antimicrobial activity of some new thienopyrimidine derivatives

Abstract

Due to the biological activities of pyrimidine and thienopyrimidine as antimicrobial agents, so in the present work, a series of new heterocyclic compounds containing thienopyrimidine moiety were synthesized such as, tetrazolo[1′,5′:1′,6′]pyrimido[4′,5′:4, 5]thieno[2, 3-d]pyrimidine derivatives (8-12b), pyrimido[3′,2′:1′,6′]pyrim-ido[4′,5′:4, 5]thieno[2, 3-d]pyrimidine derivatives (14, 16) and pyrimido[5′,4′:4, 5]thieno[2, 3-e]pyrimido[1, 2-c] [1, 2, 3]triazine derivative (15) by using 5-amino-4-phenyl-2-(p-tolylamino)thieno[2, 3-d]pyrimidine-6-carbonitrile (7) as starting material. All synthesized compounds were evaluated for their antimicrobial activity. And Compounds (8-13) exhibited high antibacterial activity. Also, compounds (12b-18) exhibited high antifungal activity.