Nanoparticle-induced Ferroptosis for Cancer Therapy

Abstract

Ferroptosis is a recently identified form of non-apoptotic regulated cell death (RCD). It is primarily characterized by the accumulation of lipid peroxide, which is iron-dependent. Ferroptosis is essential for the treatment of tumors, renal failure, and ischemia reperfusion exposure (IRI). Ferroptosis and nanomedicine are now the subjects of intense study and clinical attention. There is, however, a limited amount of data on the precise molecular pathways behind ferroptosis and the contribution of nanoparticles. This work provides a thorough overview of ferroptosis, its regulations, and the various mechanisms by which iron- and non-iron-based nanoparticles potentially trigger ferroptosis in the context of cancer therapy. We investigated the most recent developments in ferroptosis research and nanoparticles as ferrotosis-inducing agents by performing extensive literature studies based on the notion of ferroptosis and cancer therapy and a thorough examination of various publications regarding nanoparticles. Our results suggest that tumor suppression and treatment efficacy can both be enhanced by ferroptosis triggered via nanoparticles. New ideas and viewpoints have also been put out for the treatment of ferroptosis-induced cancer, which will make a significant contribution to cancer therapy.