Dayak Onion Tuber (Eleutherine Bulbosa (Mill) (Urb) Extract Ethanol Test on The Histopatological Description of Pancreas Wistar Rat Inducted Streptozotocin

Abstract

This study aimed to determine the effect of Dayak Union tuber (Eleutherine bulbosa (Mill) Urb) ethanol extract on the regeneration of pancreatic β cells of Wistar rats induced streptozotocin. This research is laboratory experimental study by using 30 rats, they are divided into 5 groups, each group consisting of 6 rats, they are group 1 (normal control), group 2 (sick control) was given Na CMC 1 % b/v, Group 3 (positive control) was given glibenclamide at a dose of 0.25 mg / KgBW, Group 4,5 and 6 were given (Eleutherine bulbosa (Mill) Urb) extract at a dose of 125 mg / KgBB, 250 mg / KgBB and 500 mg / kgBW orally for 15 consecutive days. The histopathological damage level of the pancreas was observed with HE staining using a 400x magnification Olympus Cx-21 microscope. The result of the study showed that there were secondary metabolites of alkaloids, flavonoids, saponins, steroids, and tannins in the ethanol extract of Eleutherine palmifolia (Mill) Urb); The histopathological description showed that the damage to the structure of Langerhans islands and only a dose of 500 mg / KgBB the ethanol extract of Eleutherine palmifolia (Mill) Urb) showed improvement. Keywords: Dayak Onion Tuber; histopathological; extract ethanol