Protein superglue that holds VWF together

Abstract

In this issue of Blood, Zhou and Springer report on the structure determination of the von Willebrand factor (VWF) C-terminal cysteine knot domain (CTCK), finally uncovering the structural basis for the super-stable CTCK dimer that underpins platelet adhesion.1 © 2014 by The American Society of Hematology.