Hepatoprotective effects of Garcinia kola seed against hepatotoxicity induced by carbon tetrachloride in rats

Abstract

The protective effects of Garcinia kola against a dose of Carbon-Tetrachloride (CC1 4)-induced liver damage in experimental rats were investigated. The CC1 4 induction (administered intraperitoneally, 0.5m1/kg body weight in olive oil-0.5ml/kg body weight) led to significant increases in the levels of serum aspartate and alanine amino transferases, alkaline phosphatase and lipid peroxides in CC1 4 intoxicated rats. Pretreatment with varied concentrations of Garcinia kola diets (1%, 5% and 10%) and vitamin E (9%,) for 21 days prior to CC1 4 administration resulted in significant decreases in Liver marker enzymes and lipid peroxides. These findings suggest that Garcinia kola seed may be acting as a natural antioxidant that prevents hepatic oxidative stress induced by CC1 4