A simple high-performance liquid chromatographic practical approach for determination of flurbiprofen

26Citations
Citations of this article
29Readers
Mendeley users who have this article in their library.
Get full text

Abstract

A simple, rapid, sensitive, and specific high-performance liquid chromatography (HPLC) assay for flurbiprofen has been developed and validated practically. The chromatography was conducted using Gemini C18 column (5 μm; 4.6 mm × 250 mm, Phenomenex, California, USA). The mobile phase containing disodium hydrogen phosphate solution (30 mM) pH 7.0 and acetonitrile (50:50); and the isocratic flow rate of 1.0 ml/min were used in the current study. Detection was made at 247 nm. The calibration curve was linear (r ≥ 0.9996) over the concentration range of 5-50 µm/ml. Mean percentage (%) recovery ± % relative standard deviation (RSD) ranged from 97.07 ± 0.008 to 103.66 ± 0.013. Within-day and between-day precision were also in acceptable range of 98.83 ± 0.004 to 104.56 ± 0.009. In order to confirm the practical applicability of the method developed, flurbiprofen controlled release matrix tablets were subjected to the dissolution studies and the release rate was analyzed. The reported HPLC for flurbiprofen provides several advantages of simplicity, high specificity, accuracy, and very short run-cycle time. It is suggested that the method should be used for the routine quality control analysis of flurbiprofen pure drug and its dosage forms.

Cite

CITATION STYLE

APA

Akhlaq, M., Khan, G. M., Wahab, A., Khan, A., Hussain, A., Nawaz, A., & Abdelkader, H. (2011). A simple high-performance liquid chromatographic practical approach for determination of flurbiprofen. Journal of Advanced Pharmaceutical Technology and Research, 2(3), 151–155. https://doi.org/10.4103/2231-4040.85529

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free