Studies on the constituents of Broussonetia species. III. Two new pyrrolidine alkaloids, broussonetines G and H, as inhibitors of glycosidase, from Broussonetia kazinoki SIEB

Abstract

Two new pyrrolidine alkaloids, broussonetines G and H, were isolated from the branches of Broussonetia kazinoki Sieb. (Moraceae). Broussonetines G and H were formulated as 2β-hydroxymethyl-3α,4β-dihydroxy-5α-(1-hydroxy- 6:10;10:13-diepoxytridecyl)-pyrrolidine (1) and 2β-hydroxymethyl-3α,4β- dihydroxy-5α-(1-hydroxy-5:9;9:13-diepoxytridecyl)-pyrrolidine (2), respectively, by spectroscopic methods. 1 and 2 inhibited β-glucosidase, β- galactosidase and β-mannosidase.