Myocardial pathological changes in overtraining exercise

Abstract

Excessive training practices without sufficient recovery period (overtraining) may be influential to promote myocardial injury. The aim of this study was to tested the hypothesis that overtraining exercise caused myocardial changes within histopathobiological analysis in rats. In this study, male wistar rats (n = 16) underwent ten weeks of overtraining weeks. Rats were divided into 2 groups: 1) controls (swam 15 minute/day, 5 days/week) and 2) overstrained rats that in 6 week swam twice a day for 1 hour. After sacrificing, the hearts excised for pathological preparation slides. There was significant difference in morphologic histopathological slides between groups. Compared to controlled groups, there was histopathological analysis showed increased chromatin activity fragmentation of myocardial structure in the overstrained group. Hypertrophic of left ventricle also higher in overstrained groups than control. Necrotic bodies spread in left ventricles myocardium of overstrained groups and there were not found in controlled group. The results of study gives an add it ion of evidence about negative effects of overtraining for myocardium. Furthermore, this study shows that avoiding overtraining should be an important rules in order to protect that myocardial injury and needed for an extended investigations.