Hyperinsulinemia in African-American adolescents compared with their american white peers despite similar insulin sensitivity: A reflection of upregulated β-cell function?

Abstract

OBJECTIVE - African-American (AA) children are hyperinsulinemic and insulin resistant compared with American white (AW) children. Previously, we demonstrated that insulin secretion relative to insulin sensitivity was ∼75% higher in AA compared with AW children, suggesting that hyperinsulinemia in AA children is not merely a compensatory response to lower insulin sensitivity. The aim of the present investigation was to assess whether glucose-stimulated insulin response is higher in AA versus AW adolescents who have comparable in vivo insulin sensitivity. RESEARCH DESIGN AND METHODS - The hyperinsulinemic- euglycemic and hyperglycemic clamp techniques were utilized to assess first- and second-phase insulin secretion. Insulin secretion relative to insulin sensitivity was calculated as the glucose disposition index. RESULTS - AA adolescents compared with their AW peers with comparable insulin sensitivity and body composition had higher first-phase insulin concentrations. CONCLUSIONS - The quantitative relationship between insulin sensitivity and first-phase insulin appears to differ among AA and AW adolescents. © 2008 by the American Diabetes Association.