Hospitalization increases while economic status deteriorates in late stages of chronic obstructive pulmonary disease: The Korean National Health and Nutrition Examination Survey for 2007 2015

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is associated with frequent hospitalizations, higher mortality, and healthcare costs. Low-income COPD patients have higher rates of emergency department visits and hospitalization due to COPD exacerbation. However, other causes of admissions and their economic burden have not been well-elucidated. Methods: We analyzed the Korean National Health and Nutrition Examination Survey (KNHANES) dataset for 2007 2015. The diagnosis and staging of COPD were based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. Results: Among the 97,622 participants in KNHANES for 2007 2015, we selected 33,963 participants (4,430 with and 29,533 without COPD) aged ≥40 years, who underwent spirometry, and provided the admission history for the previous year. Participants with COPD had a higher admission rate than those without COPD (12.8% vs. 10.4%, P<0.001) The admission rate increased as the stage of COPD advanced from GOLD 1 to GOLD 4 for total causes (11.5%, 13.6%, 15.1%, and 25.0%, respectively P<0.001) and respiratory illnesses (0.5%, 1.3%, 4.6%, and 12.5%, respectively, P<0.001) The proportion of the lowest quartile household income increased in the late stages of COPD (GOLD 1 4; 35.2%, 32.1%, 44.9%, and 70.8%, respectively P<0.001). Conclusions: The hospitalization rate increased in advanced COPD, while GOLD stages 3 and 4 were associated with deterioration in economic status.