Neurally adjusted ventilatory assist for neonatal respiratory support

Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows: To determine whether NAVA compared to other forms of triggered ventilation results in reduced rates of BPD or death in newborn infants, either used as a primary or rescue mode of ventilation. To assess the safety of NAVA by determining if there is a greater risk of episodes of hypocarbia or hypercarbia, intraventricular haemorrhage, periventricular leukomalacia, or air leaks compared to other forms of triggered ventilation. Secondary objectives will be to determine whether any benefits differ by gestational age (term or preterm). In crossover trials, outcomes include peak pressure requirements, oxygenation index and the work of breathing.