Resveratrol modulates interleukin-1β-induced phosphatidylinositol 3-kinase and nuclear factor κb signaling pathways in human tenocytes

Abstract

Background: Resveratrol has been proposed to have beneficial health effects due to its anti-inflammatory properties. Results: Resveratrol suppressed IL-1β-induced activation of NF-κB and PI3K in a dose- and time-dependent manner. Conclusion: Anti-inflammatory effects of resveratrol may be mediated at least in part through inhibition/deacetylation of PI3K and NF-κB. Significance: Activated Sirt-1 plays an essential role in anti-inflammatory effects of resveratrol. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.