HIV-1 protein NEF inhibits activity of ATP-binding cassette transporter A1 by targeting endoplasmic reticulum chaperone calnexin

Abstract

Results: Nef binds to calnexin and disrupts its interaction with ABCA1 but enhances calnexin interaction with viral gp160. Conclusion: Nef regulates activity of calnexin to favor maturation of HIV gp160 at the expense of ABCA1. Significance: Learning how Nef regulates activity of calnexin is crucial for designing therapeutic strategies aimed at treating HIV infection and HIV-associated atherosclerosis. Background: HIV-1 Nef inhibits activity of ABCA1 and suppresses cholesterol efflux.