Discovering antibiotics from the global microbiome

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Abstract

Metagenomic sequencing, bioinformatic analysis and heterologous expression of an orphan biosynthetic gene cluster widely found in the environment led to the discovery and structural characterization of a novel group of calcium-dependent antibiotics hidden in plain sight.

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Lam, Y. C., & Crawford, J. M. (2018, April 1). Discovering antibiotics from the global microbiome. Nature Microbiology. Nature Publishing Group. https://doi.org/10.1038/s41564-018-0135-5

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