Cerebellar metastasis from follicular thyroid carcinoma

Abstract

© 2016 Sociedad Española de Anatomía Patológica We present here, for the first time, a case of cerebellar metastasis from a follicular thyroid carcinoma. A 78 year-old woman had undergone total thyroidectomy 23 years previously for an atypical thyroid adenoma in the left thyroid lobe. Serum thyroglobulin (tg) levels subsequently increased but thyroglobulin antibody levels were always negative. She received radioiodine therapy on several occasions. In the follow-up localizing study a whole body CT scan revealed an image at the left cerebellar hemisphere level. The patient underwent surgery for the cerebellar lesion and immunohistochemistry revealed it to be a metastasis of thyroid origin; the tumour cells had diffuse and intense positivity for cytokeratin-7 (CK7), thyroid transcription factor-1 (TTF-1) and tg, focal and weak positivity for CK19 and negativity for PGAF, galectin-3 and CK20. The analysis of V600K V600E BRAF gene mutations was negative.