Progress in metathesis through natural product synthesis

Abstract

This article covers case studies in natural product syntheses with comments on various aspects of metathesis reactions and on how the difficulties encountered in these syntheses have led to better understanding of these reactions or to more effective reaction conditions and catalysts. Ring-closingmetathesis leading to small and medium-sized rings is discussed, followed by macrocycle formation, asymmetric ring-closing metathesis, and cross metathesis. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.