Supplementation of catfish (Clarias gariepinus) oil enriched with omega-3 soft capsule improves oxidative stress and cognitive function in elderly

Abstract

Elderly is defined as an age group that is susceptible to various diseases. The aging process in the elderly is associated with an increase in oxidative stress activity which can lead to various health problems which are a major cause of high mortality and morbid-ity. This study aimed to analyze the effect of supplementation of catfish (Clarias gariepinus) oil enriched with omega-3 soft capsule on oxidative stress and cognitive function of elderly people. The design of this study was a single blind randomized control trial. A total of 29 elderly subjects were chosen following these inclusion criteria: aged >60 y; had dyslipid-emia; and signed the informed consent. Subject were divided into three groups i.e. SO (soy-bean oil), CFO (commercial fish oil), and CO with omega-3 (catfish oil enriched with omega-3). The intervention was 1,000 mg oil/d administered for 90 d. The results showed that different supplementation groups had significant effects on oxidative stress and cognitive function (p<0.05). Supplementation of catfish oil enriched with omega-3 was able to significantly decreased malondialdehyde (MDA) level (p<0.05) and significantly increased mini mental state examination (MMSE) score (p<0.05). Overall, CO with omega-3 supplementa-tion for 90 d was able to improve oxidative stress and cognitive function of the elderly better than other groups.