A novel modified MIL-101-NH2 ligand for CuI-catalyzed and air promoted oxidation of secondary alcohols

Abstract

An efficient Cu(i)-catalyzed aerobic alcohol oxidation system was developed utilizing a novel metal-organic framework (MOF) ligand at room temperature. Several relatively inert secondary alcohols were converted to their corresponding ketones in high yields and selectivities in the presence of a Cu(i) catalyst and air as the oxidant. This newly developed Cu(i)/MOF ligand system can also be easily extended to the aerobic oxidation of primary alcohols including aliphatic ones. Furthermore, the MIL-101-N-2-pyc ligand can be recycled several times without compromising reaction activity.