Postmortem findings for 7 neonates with congenital Zika virus infection

Abstract

Postmortem examination of 7 neonates with congenital Zika virus infection in Brazil revealed microcephaly, ventriculo-megaly, dystrophic calcifications, and severe cortical neuronal depletion in all and arthrogryposis in 6. Other findings were leptomeningeal and brain parenchymal inflammation and pulmonary hypoplasia and lymphocytic infiltration in liver and lungs. Findings confirmed virus neurotropism and multiple organ infection.