Fabrication and Characterization of Magnetic Nanoparticles-Embedded Polymer Blend Matrix of Sodium Alginate/Gellan Gum Beads for the Controlled Release of Amikacin Sulfate

Abstract

Background: Magnetic nanoparticles are valued in medical applications for their distinctive properties. In this study, we synthesized magnetic nanoparticles with the aim of employing them for drug delivery. Materials and Methods: The nanoparticles were synthesized through the co-precipitation of ferric and ferrous salts. Subsequently, these nanoparticles were incorporated into a sodium alginate-gellan gum polymeric matrix and prepared into microbeads by the ionotropic gelation method. The microbeads underwent characterization through various techniques. Results and Discussion: In vitro release studies were conducted to assess the release of amikacin sulfate from the microbeads, and to examine the influence of crosslinking agents and polymer concentrations. Our findings suggest that the microbeads effectively control the release of amikacin sulfate. Conclusion: Our study demonstrates the potential of magnetic nanoparticles in drug delivery, particularly through sodium alginate-gellan gum microbeads as controlled-release carriers, offering promising prospects for medical applications.