A New Synthesis of (±)-Agarospirol and (±)-Hinesol

Abstract

(±)-Agarospirol (8) and (±)-hinesol (9) were simultaneously synthesized via a useful synthon in the synthesis of spirovetivane-type sesquitcrpenes, i.e., (2S*, 5S*,10R*)-2-hydroxy-6,10-dimethylspiro[4.5]dec-6-on-8-one (1), which had previously been prepared from the corresponding phenolic α-diazoketonc via the spiro-annelation reaction and subsequent stereo-controlled Birch reduction, both reported in our previous communications. © 1982, The Pharmaceutical Society of Japan. All rights reserved.