Clarification of MPC and the mutant selection window concept [1]

Abstract

In summary, the mutant selection window hypothesis may have broad applications for fighting the growing problem of antimicrobial resistance. Although an easily measurable MPC or a well defined mutant selection window does not necessarily mean that an agent can be dosed above the window to suppress development of resistance, such measurements do provide guidance as to whether a compound can be used as monotherapy or whether it is better combined with another compatible compound.