The role of skin and gut microbiome in atopic dermatitis

Abstract

Atopic dermatitis is a polyetiologically determined chronic inflammatory disease of children and adults. It presents with various phenotypes, depending on the many genetic and epigenetic factors implicated in its onset. The onset of the disease has been linked to changes and imbalances in skin and gut microbiome, among other factors. The optimal treatment of atopic dermatitis must be individually tailored to each patient, which is very challenging. In light of recent findings on the role of microbiome in the onset and recurrence of the disease, products that affect the regulation of the altered skin and gut microbiome are also important in the therapy.