An ABC for Scott syndrome?

Abstract

Scott syndrome is an extremely rare inherited hemorrhagic disorder linked to the lack of exposure of procoagulant phosphatidylserine (PS) to the external leaflet of the plasma membrane of activated platelets and other hematologic lineages. The loss of membrane lipid asymmetry, however, occurs in virtually all eukaryotic cells upon stimulation (including apoptosis) and is associated with more ancestral functions than hemostasis. Hence, it is of prime interest to identify effectors of this basic process.